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Publications in the selection

21 hits

Bibliografisk träff 2023-07-19

A preclinical secondary pharmacology resource illuminates target-adverse drug reaction associations of marketed drugs.

Sutherland JJ, Yonchev D, Fekete A, Urban L.

Nat Commun · research support, non-u.s. gov't; research-article; journal article · DOI 10.1038/s41467-023-40064-9

Bibliografisk träff 2016-03-03

DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans.

Chen M, Suzuki A, Thakkar S, Yu K, Hu C, Tong W.

Drug Discov Today · review; journal article · DOI 10.1016/j.drudis.2016.02.015

Bibliografisk träff 2015-01-08

Interaction of human organic anion transporter polypeptides 1B1 and 1B3 with antineoplastic compounds.

Marada VV, Flörl S, Kühne A, Burckhardt G, Hagos Y.

Eur J Med Chem · research support, non-u.s. gov't; journal article · DOI 10.1016/j.ejmech.2015.01.011

Bibliografisk träff 2013-08-16

A multifactorial approach to hepatobiliary transporter assessment enables improved therapeutic compound development.

Morgan RE, van Staden CJ, Chen Y, Kalyanaraman N, Kalanzi J, Dunn RT, Afshari CA, Hamadeh HK.

Toxicol Sci · journal article · DOI 10.1093/toxsci/kft176

Bibliografisk träff 2013-04-09

Structure-based identification of OATP1B1/3 inhibitors.

De Bruyn T, van Westen GJ, Ijzerman AP, Stieger B, de Witte P, Augustijns PF, Annaert PP.

Mol Pharmacol · research support, non-u.s. gov't; journal article · DOI 10.1124/mol.112.084152

Bibliografisk träff 2012-09-07

Mitigating the inhibition of human bile salt export pump by drugs: opportunities provided by physicochemical property modulation, in silico modeling, and structural modification.

Warner DJ, Chen H, Cantin LD, Kenna JG, Stahl S, Walker CL, Noeske T.

Drug Metab Dispos · journal article · DOI 10.1124/dmd.112.047068

Bibliografisk träff 2012-05-15

Classification of inhibitors of hepatic organic anion transporting polypeptides (OATPs): influence of protein expression on drug-drug interactions.

Karlgren M, Vildhede A, Norinder U, Wisniewski JR, Kimoto E, Lai Y, Haglund U, Artursson P.

J Med Chem · research support, non-u.s. gov't; research-article; journal article · DOI 10.1021/jm300212s

Bibliografisk träff 2011-12-15

Translating clinical findings into knowledge in drug safety evaluation--drug induced liver injury prediction system (DILIps).

Liu Z, Shi Q, Ding D, Kelly R, Fang H, Tong W.

PLoS Comput Biol · research support, u.s. gov't, p.h.s.; research-article; journal article · DOI 10.1371/journal.pcbi.1002310

Bibliografisk träff 2010-09-09

Interference with bile salt export pump function is a susceptibility factor for human liver injury in drug development.

Morgan RE, Trauner M, van Staden CJ, Lee PH, Ramachandran B, Eschenberg M, Afshari CA, Qualls CW, Lightfoot-Dunn R, Hamadeh HK.

Toxicol Sci · journal article · DOI 10.1093/toxsci/kfq269

Bibliografisk träff 2009-08-01

Physicochemical determinants of human renal clearance.

Varma MV, Feng B, Obach RS, Troutman MD, Chupka J, Miller HR, El-Kattan A.

J Med Chem · journal article · DOI 10.1021/jm900403j

Bibliografisk träff 2008-10-04

Quantitative structure-activity relationship and complex network approach to monoamine oxidase A and B inhibitors.

Santana L, González-Díaz H, Quezada E, Uriarte E, Yáñez M, Viña D, Orallo F.

J Med Chem · research support, non-u.s. gov't; journal article · DOI 10.1021/jm800656v

Bibliografisk träff 2008-04-21

Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds.

Obach RS, Lombardo F, Waters NJ.

Drug Metab Dispos · journal article · DOI 10.1124/dmd.108.020479

Bibliografisk träff 2007-12-05

Structure-activity relationships of novel heteroaryl-acrylonitriles as cytotoxic and antibacterial agents.

Saczewski F, Stencel A, Bieńczak AM, Langowska KA, Michaelis M, Werel W, Hałasa R, Reszka P, Bednarski PJ.

Eur J Med Chem · research support, non-u.s. gov't; journal article · DOI 10.1016/j.ejmech.2007.11.017

Bibliografisk träff 2005-10-01

Cytochrome p450 enzymes mechanism based inhibitors: common sub-structures and reactivity.

Fontana E, Dansette PM, Poli SM.

Curr Drug Metab · systematic review; journal article · DOI 10.2174/138920005774330639

Bibliografisk träff 2004-12-01

Assessment of the health effects of chemicals in humans: II. Construction of an adverse effects database for QSAR modeling.

Matthews EJ, Kruhlak NL, Weaver JL, Benz RD, Contrera JF.

Curr Drug Discov Technol · journal article · DOI 10.2174/1570163043334794

Bibliografisk träff 2004-08-01

[Drug-induced liver injury; fourteenth updated edition of the bibliographic database of liver injuries and related drugs].

Biour M, Ben Salem C, Chazouillères O, Grangé JD, Serfaty L, Poupon R.

Gastroenterol Clin Biol · bibliography; journal article · DOI 10.1016/s0399-8320(04)95062-2

Bibliografisk träff 1996-01-01

Synthesis and antitumor evaluation of a highly potent cytotoxic DNA cross-linking polyamine analogue, 1,12-diaziridinyl-4,9-diazadodecane.

Li Y, Eiseman JL, Sentz DL, Rogers FA, Pan SS, Hu LT, Egorin MJ, Callery PS.

J Med Chem · research support, u.s. gov't, p.h.s.; research support, non-u.s. gov't; journal article · DOI 10.1021/jm9500885

Bibliografisk träff 1990-07-01

Structure-activity relationships of antineoplastic agents in multidrug resistance.

Selassie CD, Hansch C, Khwaja TA.

J Med Chem · journal article · DOI 10.1021/jm00169a014

Bibliografisk träff 1986-11-01

In the search for new anticancer drugs. 19. A predictive design of N,N:N',N':N'',N''-tri-1,2-ethanediylphosphorothioic triamide (TEPA) analogues.

Sosnovsky G, Rao NU, Li SW.

J Med Chem · research support, non-u.s. gov't; journal article · DOI 10.1021/jm00161a016

Bibliografisk träff 1986-07-01

In the search for new anticancer drugs. 17. Linear and cyclic polyether analogues of N,N:N',N':N'',N''-tri-1,2-ethanediylphosphoric triamide and N,N:N',N':N'',N''-tri-1,2-ethanediylphosphorothioic triamide.

Sosnovsky G, Lukszo J, Rao NU.

J Med Chem · comparative study; research support, non-u.s. gov't; journal article · DOI 10.1021/jm00157a023

Bibliografisk träff 1984-06-01

In the search for new anticancer drugs. 9. Synthesis and anticancer activity of spin-labeled analogues of N,N:N',N':N",N"-Tri-1,2-ethanediylphosphoric triamide and N,N:N',N':N",N"-tri-1,2-ethanediylphosphorothioic triamide.

Sosnovsky G, Paul BD.

J Med Chem · research support, non-u.s. gov't; journal article · DOI 10.1021/jm00372a014