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Publikationer i urvalet

14 träffar

Bibliografisk träff 2020-07-03

rDNA Chromatin Activity Status as a Biomarker of Sensitivity to the RNA Polymerase I Transcription Inhibitor CX-5461.

Son J, Hannan KM, Poortinga G, Hein N, Cameron DP, Ganley ARD, Sheppard KE, Pearson RB, Hannan RD, Sanij E.

Front Cell Dev Biol · research-article; journal article · DOI 10.3389/fcell.2020.00568

Bibliografisk träff 2020-05-26

CX-5461 activates the DNA damage response and demonstrates therapeutic efficacy in high-grade serous ovarian cancer.

Sanij E, Hannan KM, Xuan J, Yan S, Ahern JE, Trigos AS, Brajanovski N, Son J, Chan KT, Kondrashova O, Lieschke E, Wakefield MJ, Frank D, Ellis S, Cullinane C, Kang J, Poortinga G, Nag P, Deans AJ, Khanna KK, Mileshkin L, McArthur GA, Soong J, Berns EMJJ, Hannan RD, Scott CL, Sheppard KE, Pearson RB.

Nat Commun · research support, non-u.s. gov't; research-article; journal article · DOI 10.1038/s41467-020-16393-4

Bibliografisk träff 2020-05-15

A Multimodal Genotoxic Anticancer Drug Characterized by Pharmacogenetic Analysis in <i>Caenorhabditis elegans</i>.

Ye FB, Hamza A, Singh T, Flibotte S, Hieter P, O'Neil NJ.

Genetics · research support, non-u.s. gov't; research-article; journal article; research support, n.i.h., extramural · DOI 10.1534/genetics.120.303169

Bibliografisk träff 2020-02-10

The primary mechanism of cytotoxicity of the chemotherapeutic agent CX-5461 is topoisomerase II poisoning.

Bruno PM, Lu M, Dennis KA, Inam H, Moore CJ, Sheehe J, Elledge SJ, Hemann MT, Pritchard JR.

Proc Natl Acad Sci U S A · research support, non-u.s. gov't; research-article; journal article; research support, n.i.h., extramural · DOI 10.1073/pnas.1921649117

Bibliografisk träff 2019-12-04

CX-5461 Inhibits Pancreatic Ductal Adenocarcinoma Cell Growth, Migration and Induces DNA Damage.

El Hassouni B, Mantini G, Immordino B, Peters GJ, Giovannetti E.

Molecules · research-article; journal article · DOI 10.3390/molecules24244445

Bibliografisk träff 2019-09-25

The Targeting of RNA Polymerase I Transcription Using CX-5461 in Combination with Radiation Enhances Tumour Cell Killing Effects in Human Solid Cancers.

Ismael M, Webb R, Ajaz M, Kirkby KJ, Coley HM.

Cancers (Basel) · research-article; journal article · DOI 10.3390/cancers11101429

Bibliografisk träff 2019-08-09

Discovery of novel inhibitors of ribosome biogenesis by innovative high throughput screening strategies.

Scull CE, Zhang Y, Tower N, Rasmussen L, Padmalayam I, Hunter R, Zhai L, Bostwick R, Schneider DA.

Biochem J · research support, non-u.s. gov't; research-article; journal article; research support, n.i.h., extramural · DOI 10.1042/bcj20190207

Bibliografisk träff 2019-05-15

First-in-Human RNA Polymerase I Transcription Inhibitor CX-5461 in Patients with Advanced Hematologic Cancers: Results of a Phase I Dose-Escalation Study.

Khot A, Brajanovski N, Cameron DP, Hein N, Maclachlan KH, Sanij E, Lim J, Soong J, Link E, Blombery P, Thompson ER, Fellowes A, Sheppard KE, McArthur GA, Pearson RB, Hannan RD, Poortinga G, Harrison SJ.

Cancer Discov · research support, non-u.s. gov't; clinical trial, phase i; journal article · DOI 10.1158/2159-8290.cd-18-1455

Bibliografisk träff 2019-05-09

Abnormal Ribosome Biogenesis Partly Induced p53-Dependent Aortic Medial Smooth Muscle Cell Apoptosis and Oxidative Stress.

Wu Q, Hong J, Wang Z, Hu J, Chen R, Hu Z, Li B, Hu X, Zhang Z, Ruan Y.

Oxid Med Cell Longev · research-article; journal article · DOI 10.1155/2019/7064319

Bibliografisk träff 2019-05-03

Various Nucleolar Stress Inducers Result in Highly Distinct Changes in Water, Dry Mass and Elemental Content in Cancerous Cell Compartments: Investigation Using a Nano-Analytical Approach.

Michel J, Nolin F, Wortham L, Lalun N, Tchelidze P, Banchet V, Terryn C, Ploton D.

Nanotheranostics · research support, non-u.s. gov't; research-article; journal article · DOI 10.7150/ntno.31878

Bibliografisk träff 2019-02-28

Down-regulation of MYCN protein by CX-5461 leads to neuroblastoma tumor growth suppression.

Taylor JS, Zeki J, Ornell K, Coburn J, Shimada H, Ikegaki N, Chiu B.

J Pediatr Surg · research-article; journal article · DOI 10.1016/j.jpedsurg.2019.02.028

Bibliografisk träff 2018-12-12

Inhibitors of ribosome biogenesis repress the growth of MYCN-amplified neuroblastoma.

Hald ØH, Olsen L, Gallo-Oller G, Elfman LHM, Løkke C, Kogner P, Sveinbjörnsson B, Flægstad T, Johnsen JI, Einvik C.

Oncogene · research support, non-u.s. gov't; research-article; journal article · DOI 10.1038/s41388-018-0611-7

Bibliografisk träff 2018-07-18

Copper-CX-5461: A novel liposomal formulation for a small molecule rRNA synthesis inhibitor.

Leung AWY, Anantha M, Dragowska WH, Wehbe M, Bally MB.

J Control Release · research support, non-u.s. gov't; journal article · DOI 10.1016/j.jconrel.2018.07.025

Bibliografisk träff 2010-12-15

Targeting RNA polymerase I with an oral small molecule CX-5461 inhibits ribosomal RNA synthesis and solid tumor growth.

Drygin D, Lin A, Bliesath J, Ho CB, O'Brien SE, Proffitt C, Omori M, Haddach M, Schwaebe MK, Siddiqui-Jain A, Streiner N, Quin JE, Sanij E, Bywater MJ, Hannan RD, Ryckman D, Anderes K, Rice WG.

Cancer Res · research support, non-u.s. gov't; journal article · DOI 10.1158/0008-5472.can-10-1728