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Publikationer i urvalet

21 träffar

Bibliografisk träff 2023-10-09

Strategies for the Discovery of Oxazolidinone Antibacterial Agents: Development and Future Perspectives.

Liu P, Jiang Y, Jiao L, Luo Y, Wang X, Yang T.

J Med Chem · research support, non-u.s. gov't; review; journal article · DOI 10.1021/acs.jmedchem.3c01040

Bibliografisk träff 2019-07-16

Incorporation of a chiral gem-disubstituted nitrogen heterocycle yields an oxazolidinone antibiotic with reduced mitochondrial toxicity.

Sun AW, Bulterys PL, Bartberger MD, Jorth PA, O'Boyle BM, Virgil SC, Miller JF, Stoltz BM.

Bioorg Med Chem Lett · research support, non-u.s. gov't; research-article; journal article; research support, n.i.h., extramural · DOI 10.1016/j.bmcl.2019.07.024

Bibliografisk träff 2018-03-23

A Synthetic Dual Drug Sideromycin Induces Gram-Negative Bacteria To Commit Suicide with a Gram-Positive Antibiotic.

Liu R, Miller PA, Vakulenko SB, Stewart NK, Boggess WC, Miller MJ.

J Med Chem · research support, u.s. gov't, non-p.h.s.; journal article; research support, n.i.h., extramural · DOI 10.1021/acs.jmedchem.8b00218

Bibliografisk träff 2017-08-18

Causes and Significance of Increased Compound Potency in Cellular or Physiological Contexts.

Schwaid AG, Cornella-Taracido I.

J Med Chem · review; journal article · DOI 10.1021/acs.jmedchem.7b00762

Bibliografisk träff 2013-03-14

Antibacterial oxazolidinone analogues having a N-hydroxyacetyl-substituted seven-membered [1,2,5]triazepane or [1,2,5]oxadiazepane C-ring unit.

Suzuki H, Utsunomiya I, Shudo K, Fukuhara N, Iwaki T, Yasukata T.

Eur J Med Chem · journal article · DOI 10.1016/j.ejmech.2013.03.003

Bibliografisk träff 2008-03-14

Linezolid (ZYVOX), the first member of a completely new class of antibacterial agents for treatment of serious gram-positive infections.

Brickner SJ, Barbachyn MR, Hutchinson DK, Manninen PR.

J Med Chem · review; journal article · DOI 10.1021/jm800038g

Bibliografisk träff 2007-06-30

Synthesis and in vitro antibacterial activity of novel methylamino piperidinyl oxazolidinones.

Srivastava BK, Soni R, Patel JZ, Solanki M, Valani D, Gupta S, Mishra B, Takale V, Pandya P, Jain MR, Patel PR.

Bioorg Med Chem Lett · journal article · DOI 10.1016/j.bmcl.2007.06.075

Bibliografisk träff 2007-05-27

Synthesis and in vitro antibacterial activities of novel oxazolidinones.

Srivastava BK, Jain MR, Solanki M, Soni R, Valani D, Gupta S, Mishra B, Takale V, Kapadnis P, Patel H, Pandya P, Patel JZ, Patel PR.

Eur J Med Chem · journal article · DOI 10.1016/j.ejmech.2007.05.003

Bibliografisk träff 2006-05-02

3D QSAR studies of N-4-arylacryloylpiperazin-1-yl-phenyl-oxazolidinones: a novel class of antibacterial agents.

Lohray BB, Gandhi N, Srivastava BK, Lohray VB.

Bioorg Med Chem Lett · journal article · DOI 10.1016/j.bmcl.2006.04.023

Bibliografisk träff 2005-12-28

Novel 4-N-substituted aryl pent-2-ene-1,4-dione derivatives of piperazinyloxazolidinones as antibacterials.

Lohray BB, Lohray VB, Srivastava BK, Gupta S, Solanki M, Pandya P, Kapadnis P.

Bioorg Med Chem Lett · comparative study; journal article · DOI 10.1016/j.bmcl.2005.12.025

Bibliografisk träff 2005-06-01

Synthesis and antibacterial activity of dihydro-1,2-oxazine and 2-pyrazoline oxazolidinones: novel analogs of linezolid.

D'Andrea S, Zheng ZB, Denbleyker K, Fung-Tomc JC, Yang H, Clark J, Taylor D, Bronson J.

Bioorg Med Chem Lett · journal article · DOI 10.1016/j.bmcl.2005.03.099

Bibliografisk träff 2004-06-01

Oxazolidinone: search for highly potent antibacterial.

Lohray BB, Lohray VB, Srivastava BK, Gupta S, Solanki M, Kapadnis P, Takale V, Pandya P.

Bioorg Med Chem Lett · journal article · DOI 10.1016/j.bmcl.2004.04.024

Bibliografisk träff 2003-01-01

Identification of phenylisoxazolines as novel and viable antibacterial agents active against Gram-positive pathogens.

Barbachyn MR, Cleek GJ, Dolak LA, Garmon SA, Morris J, Seest EP, Thomas RC, Toops DS, Watt W, Wishka DG, Ford CW, Zurenko GE, Hamel JC, Schaadt RD, Stapert D, Yagi BH, Adams WJ, Friis JM, Slatter JG, Sams JP, Oien NL, Zaya MJ, Wienkers LC, Wynalda MA.

J Med Chem · journal article · DOI 10.1021/jm020248u

Bibliografisk träff 2000-08-01

Improved antibacterial activities of coumarin antibiotics bearing 5',5'-dialkylnoviose: biological activity of RU79115.

Musicki B, Periers AM, Laurin P, Ferroud D, Benedetti Y, Lachaud S, Chatreaux F, Haesslein JL, Iltis A, Pierre C, Khider J, Tessot N, Airault M, Demassey J, Dupuis-Hamelin C, Lassaigne P, Bonnefoy A, Vicat P, Klich M.

Bioorg Med Chem Lett · journal article · DOI 10.1016/s0960-894x(00)00304-8

Bibliografisk träff 2000-03-01

Substituent effects on the antibacterial activity of nitrogen-carbon-linked (azolylphenyl)oxazolidinones with expanded activity against the fastidious gram-negative organisms Haemophilus influenzae and Moraxella catarrhalis.

Genin MJ, Allwine DA, Anderson DJ, Barbachyn MR, Emmert DE, Garmon SA, Graber DR, Grega KC, Hester JB, Hutchinson DK, Morris J, Reischer RJ, Ford CW, Zurenko GE, Hamel JC, Schaadt RD, Stapert D, Yagi BH.

J Med Chem · journal article · DOI 10.1021/jm990373e

Bibliografisk träff 1999-09-01

Synthesis and in vitro activity of new oxazolidinone antibacterial agents having substituted isoxazoles.

Pae AN, Kim HY, Joo HJ, Kim BH, Cho YS, Choi KI, Choi JH, Koh HY.

Bioorg Med Chem Lett · research support, non-u.s. gov't; journal article · DOI 10.1016/s0960-894x(99)00473-4

Bibliografisk träff 1999-09-01

3D QSAR studies on new oxazolidinone antibacterial agents by comparative molecular field analysis.

Pae AN, Kim SY, Kim HY, Joo HJ, Cho YS, Choi KI, Choi JH, Koh HY.

Bioorg Med Chem Lett · comparative study; research support, non-u.s. gov't; journal article · DOI 10.1016/s0960-894x(99)00474-6

Bibliografisk träff 1998-12-01

Nitrogen-carbon-linked (azolylphenyl)oxazolidinones with potent antibacterial activity against the fastidious gram-negative organisms Haemophilus influenzae and Moraxella catarrhalis.

Genin MJ, Hutchinson DK, Allwine DA, Hester JB, Emmert DE, Garmon SA, Ford CW, Zurenko GE, Hamel JC, Schaadt RD, Stapert D, Yagi BH, Friis JM, Shobe EM, Adams WJ.

J Med Chem · journal article · DOI 10.1021/jm980546k

Bibliografisk träff 1998-09-01

Piperazinyl oxazolidinone antibacterial agents containing a pyridine, diazene, or triazene heteroaromatic ring.

Tucker JA, Allwine DA, Grega KC, Barbachyn MR, Klock JL, Adamski JL, Brickner SJ, Hutchinson DK, Ford CW, Zurenko GE, Conradi RA, Burton PS, Jensen RM.

J Med Chem · comparative study; journal article · DOI 10.1021/jm980274l

Bibliografisk träff 1996-09-01

New directions in antibacterial research.

Chu DT, Plattner JJ, Katz L.

J Med Chem · review; journal article · DOI 10.1021/jm960294s

Bibliografisk träff 1996-02-01

Synthesis and antibacterial activity of U-100592 and U-100766, two oxazolidinone antibacterial agents for the potential treatment of multidrug-resistant gram-positive bacterial infections.

Brickner SJ, Hutchinson DK, Barbachyn MR, Manninen PR, Ulanowicz DA, Garmon SA, Grega KC, Hendges SK, Toops DS, Ford CW, Zurenko GE.

J Med Chem · journal article · DOI 10.1021/jm9509556