DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans.
Chen M, Suzuki A, Thakkar S, Yu K, Hu C, Tong W.
Drug Discov Today · review; journal article · DOI 10.1016/j.drudis.2016.02.015 PUBLIKATIONSREGISTRET
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15 träffarDiscovery of β-D-2'-deoxy-2'-α-fluoro-4'-α-cyano-5-aza-7,9-dideaza adenosine as a potent nucleoside inhibitor of respiratory syncytial virus with excellent selectivity over mitochondrial RNA and DNA polymerases.
Clarke MO, Mackman R, Byun D, Hui H, Barauskas O, Birkus G, Chun BK, Doerffler E, Feng J, Karki K, Lee G, Perron M, Siegel D, Swaminathan S, Lee W.
Bioorg Med Chem Lett · journal article · DOI 10.1016/j.bmcl.2015.04.073Translating clinical findings into knowledge in drug safety evaluation--drug induced liver injury prediction system (DILIps).
Liu Z, Shi Q, Ding D, Kelly R, Fang H, Tong W.
PLoS Comput Biol · research support, u.s. gov't, p.h.s.; research-article; journal article · DOI 10.1371/journal.pcbi.1002310In vitro inhibition of the bile salt export pump correlates with risk of cholestatic drug-induced liver injury in humans.
Dawson S, Stahl S, Paul N, Barber J, Kenna JG.
Drug Metab Dispos · comparative study; journal article · DOI 10.1124/dmd.111.040758FDA-approved drug labeling for the study of drug-induced liver injury.
Chen M, Vijay V, Shi Q, Liu Z, Fang H, Tong W.
Drug Discov Today · research support, u.s. gov't, p.h.s.; journal article · DOI 10.1016/j.drudis.2011.05.007A predictive ligand-based Bayesian model for human drug-induced liver injury.
Ekins S, Williams AJ, Xu JJ.
Drug Metab Dispos · journal article · DOI 10.1124/dmd.110.035113Developing structure-activity relationships for the prediction of hepatotoxicity.
Greene N, Fisk L, Naven RT, Note RR, Patel ML, Pelletier DJ.
Chem Res Toxicol · journal article · DOI 10.1021/tx1000865Unified QSAR approach to antimicrobials. 4. Multi-target QSAR modeling and comparative multi-distance study of the giant components of antiviral drug-drug complex networks.
Prado-Prado FJ, Martinez de la Vega O, Uriarte E, Ubeira FM, Chou KC, González-Díaz H.
Bioorg Med Chem · research support, non-u.s. gov't; journal article · DOI 10.1016/j.bmc.2008.11.075Synthesis and in vitro evaluation of 5-[(18)f]fluoroalkyl pyrimidine nucleosides for molecular imaging of herpes simplex virus type 1 thymidine kinase reporter gene expression.
Chacko AM, Qu W, Kung HF.
J Med Chem · research-article; journal article; research support, n.i.h., extramural · DOI 10.1021/jm800501dSelective phosphorylation of antiviral drugs by vaccinia virus thymidine kinase.
Prichard MN, Keith KA, Johnson MP, Harden EA, McBrayer A, Luo M, Qiu S, Chattopadhyay D, Fan X, Torrence PF, Kern ER.
Antimicrob Agents Chemother · research support, non-u.s. gov't; research-article; research support, u.s. gov't, non-p.h.s.; journal article; research support, n.i.h., extramural · DOI 10.1128/aac.01447-06[Drug-induced liver injury; fourteenth updated edition of the bibliographic database of liver injuries and related drugs].
Biour M, Ben Salem C, Chazouillères O, Grangé JD, Serfaty L, Poupon R.
Gastroenterol Clin Biol · bibliography; journal article · DOI 10.1016/s0399-8320(04)95062-22'-Fluorinated arabinonucleosides of 5-(2-haloalkyl)uracil: synthesis and antiviral activity.
Griengl H, Wanek E, Schwarz W, Streicher W, Rosenwirth B, De Clercq E.
J Med Chem · research support, non-u.s. gov't; journal article · DOI 10.1021/jm00390a0131-(2-Deoxy-2-fluoro-beta-D-arabinofuranosyl)-5-ethyluracil. A highly selective antiherpes simplex agent.
Mansuri MM, Ghazzouli I, Chen MS, Howell HG, Brodfuehrer PR, Benigni DA, Martin JC.
J Med Chem · comparative study; journal article · DOI 10.1021/jm00388a021Nucleosides. 139. Synthesis and anticytomegalovirus and antiherpes simplex virus activity of 5'-modified analogues of 2'-fluoroarabinosylpyrimidine nucleosides.
Harada K, Matulic-Adamic J, Price RW, Schinazi RF, Watanabe KA, Fox JJ.
J Med Chem · comparative study; research support, u.s. gov't, p.h.s.; research support, u.s. gov't, non-p.h.s.; journal article · DOI 10.1021/jm00384a041Nucleosides. 110. Synthesis and antiherpes virus activity of some 2'-fluoro-2'-deoxyarabinofuranosylpyrimidine nucleosides.
Watanabe KA, Reichman U, Hirota K, Lopez C, Fox JJ.
J Med Chem · research support, u.s. gov't, p.h.s.; journal article · DOI 10.1021/jm00187a005