LÄR KÄNNA INGREDIENSEN

pyridoxine hydrochloride

Den här sidan gäller pyridoxine hydrochloride. När flera former ingår i en ingrediensgrupp har varje form egna källor och forskningskopplingar.

Granskad genomgång

Här finns grundbeskrivning, användning, forskningsunderlag och begränsningar. Läs källorna och vilket underlag varje avsnitt bygger på.

Vad är ingrediensen?

Myndighetsuppgift · NIH Office of Dietary Supplements (ODS)

Pyridoxinhydroklorid är den hydrokloridsalt av pyridoxin, en av de sex vitaminerna som sammantaget benämns vitamin B6. Vitamin B6 är ett vattenlösligt vitamin som naturligt finns i många livsmedel och kan även tillsättas i livsmedel eller säljas som kosttillskott.

Källor och originalutdrag

NIH Office of Dietary Supplements (ODS) ↗ · · Källans villkor

Vitamin B6 is available in multivitamins, in supplements containing other B complex vitamins, and as a stand-alone supplement [7 ]. The most common vitamin B6 vitamer in supplements is pyridoxine (in the form of pyridoxine hydrochloride [HCl]), although some supplements contain PLP. Vitamin B6 supplements are available in oral capsules or tablets (including sublingual and chewable tablets) and liquids. Absorption of vitamin B6 from supplements is similar to that from food sources and does not differ substantially among the various forms of supplements [1 ]. Although the body absorbs large pharmacological doses of vitamin B6 well, it quickly eliminates most of the vitamin in the urine [8 ].

NIH Office of Dietary Supplements (ODS) ↗ · · Källans villkor

Vitamin B6 is available in multivitamins, in supplements containing other B complex vitamins, and as a stand-alone supplement [7 ]. The most common vitamin B6 vitamer in supplements is pyridoxine (in the form of pyridoxine hydrochloride [HCl]), although some supplements contain PLP. Vitamin B6 supplements are available in oral capsules or tablets (including sublingual and chewable tablets) and liquids. Absorption of vitamin B6 from supplements is similar to that from food sources and does not differ substantially among the various forms of supplements [1 ]. Although the body absorbs large pharmacological doses of vitamin B6 well, it quickly eliminates most of the vitamin in the urine [8 ].

NIH Office of Dietary Supplements (ODS) ↗ · · Källans villkor

Vitamin B6 is available in multivitamins, in supplements containing other B complex vitamins, and as a stand-alone supplement [7 ]. The most common vitamin B6 vitamer in supplements is pyridoxine (in the form of pyridoxine hydrochloride [HCl]), although some supplements contain PLP. Vitamin B6 supplements are available in oral capsules or tablets (including sublingual and chewable tablets) and liquids. Absorption of vitamin B6 from supplements is similar to that from food sources and does not differ substantially among the various forms of supplements [1 ]. Although the body absorbs large pharmacological doses of vitamin B6 well, it quickly eliminates most of the vitamin in the urine [8 ].

NIH Office of Dietary Supplements (ODS) ↗ · · Källans villkor

Vitamin B6 is available in multivitamins, in supplements containing other B complex vitamins, and as a stand-alone supplement [7 ]. The most common vitamin B6 vitamer in supplements is pyridoxine (in the form of pyridoxine hydrochloride [HCl]), although some supplements contain PLP. Vitamin B6 supplements are available in oral capsules or tablets (including sublingual and chewable tablets) and liquids. Absorption of vitamin B6 from supplements is similar to that from food sources and does not differ substantially among the various forms of supplements [1 ]. Although the body absorbs large pharmacological doses of vitamin B6 well, it quickly eliminates most of the vitamin in the urine [8 ].

NIH Office of Dietary Supplements (ODS) ↗ · · Källans villkor

Vitamin B6 is available in multivitamins, in supplements containing other B complex vitamins, and as a stand-alone supplement [7 ]. The most common vitamin B6 vitamer in supplements is pyridoxine (in the form of pyridoxine hydrochloride [HCl]), although some supplements contain PLP. Vitamin B6 supplements are available in oral capsules or tablets (including sublingual and chewable tablets) and liquids. Absorption of vitamin B6 from supplements is similar to that from food sources and does not differ substantially among the various forms of supplements [1 ]. Although the body absorbs large pharmacological doses of vitamin B6 well, it quickly eliminates most of the vitamin in the urine [8 ].

NIH Office of Dietary Supplements (ODS) ↗ · · Källans villkor

Vitamin B6 is available in multivitamins, in supplements containing other B complex vitamins, and as a stand-alone supplement [7 ]. The most common vitamin B6 vitamer in supplements is pyridoxine (in the form of pyridoxine hydrochloride [HCl]), although some supplements contain PLP. Vitamin B6 supplements are available in oral capsules or tablets (including sublingual and chewable tablets) and liquids. Absorption of vitamin B6 from supplements is similar to that from food sources and does not differ substantially among the various forms of supplements [1 ]. Although the body absorbs large pharmacological doses of vitamin B6 well, it quickly eliminates most of the vitamin in the urine [8 ].

Vad används det för?

Myndighetsuppgift · NIH Office of Dietary Supplements (ODS)

Pyridoxinhydroklorid är den vanligaste vitaminsformen i kosttillskott och finns i multivitaminer, B‑komplexprodukter samt som fristående tillskott i kapslar, tabletter eller vätskor. Upptaget från sådana produkter är likvärdigt med intaget från mat och elimineras snabbt via urinen.

Källor och originalutdrag

NIH Office of Dietary Supplements (ODS) ↗ · · Källans villkor

Vitamin B6 is available in multivitamins, in supplements containing other B complex vitamins, and as a stand-alone supplement [7 ]. The most common vitamin B6 vitamer in supplements is pyridoxine (in the form of pyridoxine hydrochloride [HCl]), although some supplements contain PLP. Vitamin B6 supplements are available in oral capsules or tablets (including sublingual and chewable tablets) and liquids. Absorption of vitamin B6 from supplements is similar to that from food sources and does not differ substantially among the various forms of supplements [1 ]. Although the body absorbs large pharmacological doses of vitamin B6 well, it quickly eliminates most of the vitamin in the urine [8 ].

NIH Office of Dietary Supplements (ODS) ↗ · · Källans villkor

Vitamin B6 is available in multivitamins, in supplements containing other B complex vitamins, and as a stand-alone supplement [7 ]. The most common vitamin B6 vitamer in supplements is pyridoxine (in the form of pyridoxine hydrochloride [HCl]), although some supplements contain PLP. Vitamin B6 supplements are available in oral capsules or tablets (including sublingual and chewable tablets) and liquids. Absorption of vitamin B6 from supplements is similar to that from food sources and does not differ substantially among the various forms of supplements [1 ]. Although the body absorbs large pharmacological doses of vitamin B6 well, it quickly eliminates most of the vitamin in the urine [8 ].

NIH Office of Dietary Supplements (ODS) ↗ · · Källans villkor

Vitamin B6 is available in multivitamins, in supplements containing other B complex vitamins, and as a stand-alone supplement [7 ]. The most common vitamin B6 vitamer in supplements is pyridoxine (in the form of pyridoxine hydrochloride [HCl]), although some supplements contain PLP. Vitamin B6 supplements are available in oral capsules or tablets (including sublingual and chewable tablets) and liquids. Absorption of vitamin B6 from supplements is similar to that from food sources and does not differ substantially among the various forms of supplements [1 ]. Although the body absorbs large pharmacological doses of vitamin B6 well, it quickly eliminates most of the vitamin in the urine [8 ].

NIH Office of Dietary Supplements (ODS) ↗ · · Källans villkor

Vitamin B6 is available in multivitamins, in supplements containing other B complex vitamins, and as a stand-alone supplement [7 ]. The most common vitamin B6 vitamer in supplements is pyridoxine (in the form of pyridoxine hydrochloride [HCl]), although some supplements contain PLP. Vitamin B6 supplements are available in oral capsules or tablets (including sublingual and chewable tablets) and liquids. Absorption of vitamin B6 from supplements is similar to that from food sources and does not differ substantially among the various forms of supplements [1 ]. Although the body absorbs large pharmacological doses of vitamin B6 well, it quickly eliminates most of the vitamin in the urine [8 ].

Vad säger forskningen?

Myndighetens forskningssammanfattning · NIH Office of Dietary Supplements (ODS)

Myndigheten har sammanfattat att forskare har föreslagit att vitamin B6 kan minska risken för hjärt‑ och kärlsjukdom genom att sänka homocystein, men den befintliga forskningen ger lite stöd för att tillskott av vitamin B6, ensamt eller i kombination, faktiskt minskar sjukdomsrisk eller svårighetsgrad.

Källor och originalutdrag

NIH Office of Dietary Supplements (ODS) ↗ · · Källans villkor

Scientists have hypothesized that certain B vitamins (folic acid, vitamin B12, and vitamin B6) might reduce cardiovascular disease risk by lowering homocysteine levels [1 ,13 ].

NIH Office of Dietary Supplements (ODS) ↗ · · Källans villkor

The research to date provides little evidence that supplemental amounts of vitamin B6, alone or with folic acid and vitamin B12, can help reduce the risk or severity of cardiovascular disease and stroke.

Sammanställningen bygger på utvalda originalutdrag. Den är ingen samlad bedömning eller rekommendation att använda ett tillskott.

Företagsuppgifter och hälsopåståenden · genomgång saknas ännu

Ingen separat företagskälla ingår i den här profilen. Därför bedöms inga företagspåståenden här.

Vad behöver resultatet vägas mot?

Myndighetsuppgift · NIH Office of Dietary Supplements (ODS)

Höga intag av vitamin B6 från livsmedel har inte rapporterats ge biverkningar, men kronisk konsumtion av 1–6 g pyridoxin per dag under flera månader kan leda till allvarlig sensorisk neuropati med ataxi, där svårighetsgraden beror på dosen och symtomen upphör när tillskottet avbryts.

Källor och originalutdrag

NIH Office of Dietary Supplements (ODS) ↗ · · Källans villkor

High intakes of vitamin B6 from food sources have not been reported to cause adverse effects [1 ].

NIH Office of Dietary Supplements (ODS) ↗ · · Källans villkor

However, chronic administration of 1–6 g oral pyridoxine per day for 12–40 months can cause severe and progressive sensory neuropathy characterized by ataxia (loss of control of bodily movements) [10 ,30-33 ].
Kemisk fördjupning · fler namn, identifierare och källuppgifter

Kemiska källuppgifter

Molekylformel
C8H11NO3.HCl
Laddning
0
Molekylmassa
205.641
InChIKey
ZUFQODAHGAHPFQ-UHFFFAOYSA-N
SMILES
Cc1ncc(CO)c(CO)c1O.Cl
Källans klassificering
3:STAR

Synonymer

EXACT är källans exakta synonym. RELATED, BROAD och NARROW kan vara relaterade, bredare eller snävare benämningar. Sådana namn innebär inte automatiskt samma identitet.

  • 2-methyl-3-hydroxy-4,5-bis(hydroxymethyl)pyridine hydrochloride RELATED
  • 3-hydroxy-4,5-dimethylol-alpha-picoline hydrochloride RELATED
  • 4,5-bis(hydroxymethyl)-2-methylpyridin-3-ol hydrochloride EXACT
  • 4,5-bis(hydroxymethyl)-2-methylpyridin-3-ol hydrochloride RELATED
  • 5-hydroxy-6-methyl-3,4-pyridinedimethanol hydrochloride RELATED
  • pyridoxol hydrochloride RELATED
  • vitamin B6 hydrochloride RELATED

Referenser i EFSA OpenFoodTox

ChEBI och EFSA anger följande identiska källidentifierare. Referenserna är ingen sammanslagning av ämnesposter eller bedömning av effekt och säkerhet.

EFSA OpenFoodTox · CC BY-ND 4.0 · Originaluppgifter med bevarad källversion.

Definition

The hydrochloride salt of pyridoxine.

Källans text; inga egna slutsatser har lagts till.

Identifierare i källan

  • agr: IND500675659
  • beilstein: 3632435
  • cas: 58-56-0
  • drugbank: DBSALT000151
  • foodb.food: FDB000575
  • gmelin: 1067921
  • kegg.drug: D02179
  • pubmed: 15098856
  • pubmed: 17416572
  • pubmed: 17891511
  • pubmed: 18243627
  • pubmed: 19481898
  • pubmed: 20645279
  • pubmed: 21781646
  • pubmed: 24421551
  • pubmed: 27468034
  • pubmed: 28095734
  • pubmed: 32460509
  • pubmed: 33209152
  • pubmed: 33936292
  • pubmed: 34140989

Relationer och ämnesformer

Besläktade ämnen och beståndsdelar

Följ hur ämnet hänger ihop med andra kemiska identiteter.

  • pyridoxine

    Har beståndsdel

    Kopplingens underlag

    pyridoxine hydrochloride → pyridoxine
    BFO:0000051 · 57d1418b-0a23-4636-b807-c1f49501dc4b

    Originalregister
Fördjupning · ämnesklasser och roller
  • vitamin B6

    Tillhör ämnesklassen

    Kopplingens underlag

    pyridoxine hydrochloride → vitamin B6
    is_a · 57d1418b-0a23-4636-b807-c1f49501dc4b

    Originalregister
  • antitubercular agent

    Har källklassificerad roll

    Kopplingens underlag

    pyridoxine hydrochloride → antitubercular agent
    RO:0000087 · 57d1418b-0a23-4636-b807-c1f49501dc4b

    Originalregister
  • hydrochloride

    Tillhör ämnesklassen

    Kopplingens underlag

    pyridoxine hydrochloride → hydrochloride
    is_a · 57d1418b-0a23-4636-b807-c1f49501dc4b

    Originalregister
  • anti-anaemic agent

    Har källklassificerad roll

    Kopplingens underlag

    pyridoxine hydrochloride → anti-anaemic agent
    RO:0000087 · 57d1418b-0a23-4636-b807-c1f49501dc4b

    Originalregister

Relationer beskriver källans kemiska struktur eller klassificering. Ämnena behåller separata identiteter. Detta innebär inte samma innehåll, dosering, effekt eller säkerhet.

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Publikationer i källan

ChEBI hänvisar till 14 PubMed-publikationer för den här posten. Kopplingen är en källhänvisning och innebär ingen egen slutsats om effekt eller säkerhet.

14 publikationsposter har hämtats hittills. Registret fylls automatiskt.

Bibliografisk träff 2021-06-09

Assessment of a feed additive consisting of vitamin B6 (pyridoxine hydrochloride) for all animal species for the renewal of its authorisation (Kaesler Nutrition GmbH).

EFSA Panel on Additives and Products or Substances used in Animal Feed (FEEDAP), Bampidis V, Azimonti G, Bastos ML, Christensen H, Dusemund B, Fašmon Durjava M, Kouba M, López-Alonso M, López Puente S, Marcon F, Mayo B, Pechová A, Petkova M, Ramos F, Ramos F, Sanz Y, Villa RE, Woutersen R, Anguita M, Galobart J, Holczknecht O, Tarrés-Call J, Pettenati E, Pizzo F, Manini P.

EFSA J · research-article; journal article · DOI 10.2903/j.efsa.2021.6612
Bibliografisk träff 2020-11-13

Assessment of the application for renewal of authorisation of pyridoxine hydrochloride (vitamin B6) as a feed additive for all animal species.

EFSA Panel on Additives and Products or Substances used in Animal Feed (FEEDAP), Bampidis V, Azimonti G, Bastos ML, Christensen H, Dusemund B, Fašmon Durjava M, Kouba M, López-Alonso M, López Puente S, Marcon F, Mayo B, Pechová A, Petkova M, Ramos F, Ramos F, Sanz Y, Villa RE, Woutersen R, Anguita M, Galobart J, Holczknecht O, Tarrés-Call J, Pettenati E, Pizzo F, Manini P.

EFSA J · research-article; journal article · DOI 10.2903/j.efsa.2020.6289
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Ämnet i källregistren

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Källversioner

ChEBI 255 ·

ChEBI · EMBL-EBI · CC BY 4.0 · CC BY 4.0

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